New thermosensitive plasmid for gram-positive bacteria

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New thermosensitive plasmid for gram-positive bacteria.

We isolated a replication-thermosensitive mutant of the broad-host-range replicon pWV01. The mutant pVE6002 is fully thermosensitive above 35 degrees C in both gram-negative and gram-positive bacteria. Four clustered mutations were identified in the gene encoding the replication protein of pVE6002. The thermosensitive derivative of the related plasmid pE194 carries a mutation in the analogous r...

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ژورنال

عنوان ژورنال: Journal of Bacteriology

سال: 1992

ISSN: 0021-9193,1098-5530

DOI: 10.1128/jb.174.17.5633-5638.1992